http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-298024-B6
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 1996-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a2209624c87d68f99b87c59feeee244 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6169133f5284ba884e0af6278fae3c0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24fc692326efd6a15fac4a0195b64f11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a990bb8f22c89b5327f93bdfd0714bb9 |
| publicationDate | 2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-298024-B6 |
| titleOfInvention | Methods for preparing monomeric conjugates of carrier and calicheamicin derivative |
| abstract | A method for preparing monomeric conjugates of calicheamicin derivative and carrier with active ingredient content, high yield and reduced agglomeration. These conjugates are prepared by incubating a calicheamicin derivative and a protein carrier in a non-nucleophilic, protein-compatible, buffered solution having a suitable pH ranging from 4.0 to 8.5, and containing a co-solvent selected from the group consisting of propylene glycol, ethanol, DMSO and combinations thereof and an additive comprising at least one carboxylic acid of from 6 to 18 carbon atoms, at a temperature in the range of about 25 to 37 [deg.] C. and about 15 minutes to 24 hours; and purifying the conjugate prepared in step (1) to form monomeric conjugates. Alternatively, the conjugates can be prepared by incubating the calicheamicin derivative and the protein carrier in a solution containing non-nucleophilic, protein-compatible, buffered solution and co-solvent containing t-butanol. |
| priorityDate | 1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.