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filingDate 1998-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2007-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-297917-B6
titleOfInvention A method for producing dry amorphous products, amorphicroscopically homogeneous products and using them to use a mixture of substances to stabilize the biologically active material
abstract A method for producing dry amorphous products which, in addition to the biologically active material, contains a stabilizer. Prepare a solution or suspension of the biological material and a mixture of substances consisting of a) a saccharide and at least one zwitterion with a polar or non-polar group or a derivative and / or b) at least two zwitterions with polar or non-polar groups or their derivative and / or c) at least one zwitterionic a polar or nonpolar ion or several zwitterionic ions with polar or non-polar groups or a derivative thereof, and this is susceptible to convection drying at an inlet temperature of 100 to 180 degC using a specific drying technology with the relative moisture content of the stationary phase being set below 70%. Amorphous microscopically homogeneous products with glass transition temperature. 20 degC and residual moisture content &lt; 8% (g / g) prepared by this method and used to make diagnostic and therapeutic agents. Use of a mixture of substances to stabilize the biologically active material.
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