| abstract |
Epothilone Derivatives of Formula V ', wherein Q is selected from the group consisting of Q.sub.1 groups. and Q is 2, G is a group of formula G is 1, W is NH; X and Y are O; Z.sub.1.n. and Z.sub.2.n. are each CH.sub.2.n; B.sub.1.n. and B.sub.2.n. are OH; R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7 .n. and R.sub.12 are selected from the group consisting of hydrogen and lower alkyl; R.sub.6.n. is methyl; R.sub.8.n. is hydrogen or methyl; is selected from the group consisting of groups of formula R.sub.11.n..sup.1.n. and R 5 is hydrogen, lower alkyl or lower alkyl substituted with OH; and stereomers thereof. |