http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-296521-B6
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9433d383d1922b3df0ca6c182c7d3925 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 |
| filingDate | 1998-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15012a8267b5e644c443652546c07297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b69687d9677e3d932be8db1c5b8bfbd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c12e6450aae8dfb2b6b55f2912e1d91f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d34c9f139a954291c28efd2981b1846d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58dd7263f05d4972bf51a506d8bc1090 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeee343b62ca17fae11626efa46750c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55b6ba2674c33f82477f6da0a4c4f1c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7b7a0ebffae372b57008645c613d844 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e98ced245a1a8cdd65aa751206576fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55ff49eec8becdccae0befa172b9eee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddcc7f81191a0167701a236c1de35c15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef2d79428db4efa8f23f994651f593d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_637a8bad7237976709683f2db5cd9e4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80bb7fa87737725f93000fad9d9d4f68 |
| publicationDate | 2006-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-296521-B6 |
| titleOfInvention | Method of Preparation 1- [9'H-Carbazol-4'-yloxy] -3 - [{2''- (2'''- < / RTI > methoxy) -phenoxy) -ethyl} -amino] -propan-2-ol (carvedilol) |
| abstract | The present invention relates to a process for the preparation of 1- [9'H-carbazol-4'-yloxy] -3 - [(2 '' - (2 '' - ' -methoxy) phenoxy) ethyl} amino] -propan-2-ol , ie carvedilol, as well as its optically active R or S enantiomer, the mixture of the enantiomer and the addition salts of these compounds with an acid, by reacting a 4- (oxiranylmethoxy) -9H-carbazole or its R or S enantiomer with a secondary N- [2- ( The 2 ' - < 1 > - methoxy-phenoxy) -ethyl] -benzylamine of formula V is carried out in a protic organic solvent and the 1- [N- {benzyl} -2 ' - ({2 ' - > methoxy < / RTI > -ethyl} -amino] -3- [9 '' 'H-carbazol-4' '- yloxy] -propan-2-ol (benzylcarvedilol) is debenzylated by catalytic hydrogenation and the thus obtained 1- [9' H-carbazol-4'-yloxy] -3 - [{2 '' - (2 '' - " methoxy " -phenoxy) -ethyl} -amino] -propan-2-ol, if desired, it is reacted in a manner known per se with inorganic or organic acids to form its acid addition salts, or, if desired, the free baseecarvedilol is released. From its acid addition salts, and if desired, the free base of carvedilol is converted to other acid addition salts and / or enantiomers are separated if desired. Preferably, benzylcarvedilol is not isolated from the reaction mixture in which it was prepared before the debenzylation reaction. |
| priorityDate | 1997-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.