abstract |
Alkylaminobenzothiazole and benzoxazole derivatives of the general Formula I, their N-oxides, pharmaceutically acceptable acid addition salts and stereochemical forms thereof, wherein X is O or S; n is 2, 3, 4 or 5; R.sup.1.n. is hydrogen, C 1-6 1-6 alkyl, C 1-6 1-6 alkoxy or halogen; R.sup.2.n. is hydrogen, C 1-6 1-6 alkyl, phenyl, phenylC 1-6 alkyl or phenylcarbonyl; R.sup.3.n. and R.sup.4.n. they are independent of one another and are selected from the group consisting of hydrogen, halogen, nitro, C.sub.1-6nalkyl, C.sub.1-6n.alkoxy, halogenC.sub.1-6n. alkyl, aminosulfonyl, mono- or di (C 1-7 alkyl) alkyl aminosulfonyl, or R 6, c. and R.sup.4.n. they may together form a divalent radical of formula -CH = CH-CH = CH-, a process for their preparation, compositions containing them and their use in the treatment and / or prevention of psychotic disorders such as schizophrenia; a compound of formula I containing a radioactive isotope; a method of labeling dopamine receptor sites with D 4; and a method of imaging the organ |