| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7dfd84f9157ae12c41e319ec325338d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 |
| filingDate |
1998-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_071438774441774905e5de55196244f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58685cf43e423c8703a307596c8ff4f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b4c6240818cfd4ba651dcf12d52bdb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8237a615bdf2e6ccf5e1248b745ac518
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b14c7f70300bf1af941e036ae6af248
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7520b4324c4b711164daf24ed4838b6f |
| publicationDate |
2005-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CZ-295599-B6 |
| titleOfInvention |
Process for preparing the Z-isomer of a cephalosporin derivative |
| abstract |
Process for preparing the Z-isomer of 7-N-unsubstituted or substituted amino-3- [2- (4-substituted or unsubstituted thiazol-5-yl) vinyl] -3-cephem-4-carboxylic acid or an ester thereof of formula IV by reaction 7-N-unsubstituted or substituted amino-3 - [(trisubstituted phosphanylidene) methyl] -3-cephem-4-carboxylic acid or an ester thereof of the formula I, with a 4-substituted or unsubstituted thiazole-5-carbadehyde in a mixed solvent consists of one or more chlorinated hydrocarbons and one or more lower alkanols in a mixture in a volume ratio of from 1: 3 to 1: 0.25 at a temperature of +5 degC or less. According to this method, the production of the E-isomer of compound IV having a lower antibacterial activity than the Z-isomer can be significantly reduced. In addition, the Z-isomer can be produced with greater efficiency and ease |
| priorityDate |
1997-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |