| abstract |
The present invention relates to a pharmaceutical composition comprising a platinum complex of formula I in which A, A ', B, B', X and X 'have specific meanings, in admixture with at least one pharmaceutically acceptable excipient. that it consists of a granulate having a particle size of less than 0.5 mm, prepared by wet granulation of a water-moistened platinum tetravalent platinum complex of Formula I, at least one neutral saccharide and at least one native and / or modified polysaccharide and optionally contained in a capsule or sachet, or optionally compressed into a tablet, wherein the surface of the granulate, capsule or tablet is coated with a layer of at least one pharmaceutically acceptable substance allowing enteric dissolution of the active ingredient in the intestine and / or a layer of at least one pharmaceutically acceptable substance allowing controlled release of the active ingredient. The invention also relates to a process for the preparation of said pharmaceutical composition |