| abstract |
An isolated nucleic acid molecule encoding a chimeric TIE-2 ligand comprising at least a portion of a first TIE-2 ligand and a portion of a second TIE-2 ligand that is different from the first TIE-2 ligand, wherein the first and second TIE-2 ligands are selected from the group consisting of TIE-2 ligand 1, TIE-2 ligand 2, TIE-2 ligand 3 and TIE-2 ligand 4, is useful in the manufacture of pharmaceutical compositions for treating individuals suffering from disorders of cells, tissues or organs that express the TIE-2 receptor and for diagnostic purposes |