| abstract |
A substituted quinazoline derivative of the Formula 1 wherein X is phenyl substituted with a halogen atom; R, R.sub.1.n. and R.sub.2 .n. are hydrogen atoms; Y is a radical selected from the group of formulas, R.sub.3.n. is independently hydrogen, alkyl of 1 to 6 carbon atoms, carboxy, alkoxycarbonyl of 1 to 6 carbon atoms and phenyl; n = 2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each substituent R.sub.3. Y may be the same or different, the process for their preparation and the pharmaceutical composition thereof. The compounds are useful as antitumor drugs |