| abstract |
An omeprazole-based oral composition comprising: (a) a central portion comprising an acid-labile omeprazole as an active ingredient, the central portion comprising cores and said active ingredient, mixed together and then co-compressed, (b) an intermediate layer, and (c) the enteric layer, wherein the tablet is free of alkaline reacting compounds, and said omeprazole as active ingredient is not in the form of an alkali salt. Also included is a preparation process comprising the steps of: (i) mixing the active ingredient cores, (ii) compressing the core portion containing the active ingredient, (iii) coating the intermediate layer, and (iv) enteric coating. |