abstract |
The present invention relates to novel classes of carboxylic acid derivatives of the general formulas .alpha. and .beta., which are inhibitors of the interleukin-1beta converting enzyme. and pharmaceutical compositions containing them. The compounds and pharmaceutical compositions of the present invention are particularly useful for inhibiting ICE activity and can therefore be advantageously used as agents for interleukin-1 mediated or apoptosis mediated diseases, including inflammatory diseases, autoimmune diseases, proliferative disorders, infectious and degenerative diseases. |