| abstract |
Derivatives of rapamycin of general formula (I) wherein R 1 is n. is alkyl, alkynyl and hydroxyalkynyl; R.sub.2.n. is a group of formula II wherein R is 3. selected from the group consisting of water, alkyl, hydroxyalkyl, alkoxyalkyl or hydroxyalkoxyalkyl; R.sub.4.n. is water or methyl; and X is hydroxy or water; with the exception that when X is hydroxy and R.sub.1 is n. is an alkyl group having 1 and 6 carbon atoms, then m R.sub.3.n. another meaning not waters; and in general formula Ib in which m R.sub.1.n. is alkyl, alkenyl, hydroxyalkenyl, alk-2-ynyl, hydroxyalk-2-ynyl and alkoxyalkyl; is a defined general formula II; and their use as immunosuppressive and antiproliferative agents. |