| abstract |
Described are novel tetrahydroisoquinoline compounds of formula I and pharmaceutically acceptable salts thereof in the form of single enantiomers, racemates or other mixtures of enantiomers, wherein the substituents are as described herein, as well as O-acylated derivatives thereof, pharmaceutical compositions containing such compounds, methods of preparation these compounds by cleavage, alkylation or alkenylation of the starting materials, and the use of these novel compounds for the manufacture of a medicament for analgesia or for the treatment of psychosis, Parkinson's disease, Lesch-Nyan syndrome, attention deficit disorder or cognitive impairment, or for alleviating drug addiction or late dyskinesia. ŕ |