| abstract |
N-Substituted Aniline Derivatives of Formula 1 wherein R @ 1 is 1. is SR.sub.6.n. or NR.sub.7. where R.sub.6.n. is alkyl of 1 to 4 C or alkenyl of 2 to 6 C; R.sub.7.n. is H, alkyl of 1-6C, cycloalkyl of 3-8C, alkenyl of 2-6C, alkynyl of 3-6C, alkoxy of 1-6C, alkyl of 1-6C or nitro; R.sub.8.n. is H or alkyl of 1 to 6 C; R.sub.2.n. is H, alkyl of 1-6C, alkoxycarbonyl of 1-6C in alkoxy or carboxyl, or with R.sub.3. forming a 3- to 8-membered ring; R.sub.3.n. is H or alkyl having 1 to 6 C, or with R 2 or 2 C; forming a 3- to 8-membered ring; R.sub.4.n. is H, alkyl of 1 to 6 C, alkoxycarbonyl of 1 to 6 C in alkoxy, acetyl, benzoyl or amidino, or with R 5 is. forming a 3- to 8-membered ring; R.sub.5.n. is H, alkyl of 1 to 6 C, alkoxycarbonyl of 1 to 6 C in alkoxy, alkoxycarbonylamino of 1 to 6 C in alkoxy, or amino, or R 4 to 4, 4. forming a 3- to 8-membered ring; Y.sub.1, Y.sub.2, Y.sub.3. and Y.sub.4.n. is H, halogen, nitro, cyano, hydroxy, alkyl of 1-6C, alkenyl of 2-6C, alkynyl of 2-6C, alkoxy of 1-2C, alkylthio of 1-6C or NY.sub. 5.nYsub.6.n. or COY.sub.7, where Y.sub.5.n. and Y.sub.6.n. is H, alkyl of 1-6C, cycloalkyl of 4 or 5C, acyl of 1-8C, alkoxycarbonyl of 1-6C in alkoxy, or Y.sub.5. and Y.sub.6.n. taken together form a 3- to 8-membered ring; Y.sub.7.n. is H, hydroxy, alkyl of 1 to 6 C, or cycloalkyl of 4 or 5 C, alkoxy of 1 to 6 C or NY 5; where Y.sub.5.n. and Y.sub.6.n. is H, alkyl of 1 to 6 C or cycloalkyl of 3 to 6 C; n and m are an integer of 0 or 1; their possible stereoisomers and optically active forms, as well as pharmaceutically acceptable salts thereof |