| abstract |
Imides of the general formula I in which they have R.sub.1. and R.sub.3.n. specific meanings, R.sub.2.n. is -H or an alkyl group contains 1 and 8 carbon atoms, R < 4 > is a group -CX- or CH.sub.3 where X is an acid to or a radical, and n is 0, 1, 2 or 3. Also, pharmaceutical compositions and uses are within the scope of the invention. these compounds for inhibiting TNF.alpha.-activated retrovirus replication and for leveling TNF.alpha. in a mammal, e.g., cachexia, endotoxic eye, and retroviral replication. A typical example of these compounds is 1-phthalimido-1- (3 ', 4'-dimethoxyphenyl) propan-1-ol. |