| abstract |
The pharmaceutical composition for maintaining or increasing bone density or for inhibiting bone loss comprises the compound of formula 2-phenyl-3-aroylbenzothiophene of formula I in which R and R.sup.1 are .n. hydrogen atom, hydroxy, C.sub.1-6.n.alkoxy, C.sub.1-6.n.acyloxy, C.sub.1-6.n.alkoxyC.sub.2-6.n. an acyloxy group selected from the group consisting of phenyloxy, thienyloxy, furyloxy, naphthyloxy, benzoyloxy, thienoyloxy, furoyloxy, naphthoyloxy wherein the group is a substituent on the group R 2, a carbonyloxy substituted by a group of R.sup. 3.n. or a halogen atom, R.sup.2. C.sub.1-3 alkyl, C.sub.1-3alkoxy, hydrogen, or halogen and R.sup.3. Or a group selected from the group consisting of phenyloxy, thienyloxy, furyloxy, naphthyloxy, n 2, 3 or 4, and 4, 5 or 6, or pharmaceutically acceptable salts thereof, and solvate thereof together with a progestin selected from the group consisting of medroxyprogesterone, norethindrone and norethynodrel, or pharmaceutically acceptable salts thereof. |