| abstract |
An insulin derivative of the formula I is described, in nm Xaa at position A21 is any readable amino acid except Lys, Arg and Cys, Xaa at positions B1, B2, B3, B26, B27, B28 and B29 mean no to any other the amino acid except for Cys or omitted, the Xaa at position B30 is any other amino acid except Cys, di-, tri- and tetrapeptide not containing Cys or Arg, or omitting the amino group of the N-terminus of the amino acid. or the carboxyl group of the C-terminus of the B-amino acid amino acid moiety carries a lipophilic group of W or Z of 16 and 22 respectively. 16 and 31 are carbon atoms. Thus, a pharmaceutical composition for diabetes is described which contains a therapeutically effective amount of said insulin derivative, in admixture with insulin or an insulin analogue, which acts rapidly. |