| abstract |
7- (Substituted) -8- (substituted) -9 - [(substituted glycyl) amido] -6-demethyl-6-deoxytetracyclines of Formula I wherein X is halogen; R is H or -NR.sup.1 wherein R.sup.1 and R.sup.2 are is alkyl of 1 and 3 C; R.sup.3.n. and R.sup.4.n. is dy H; and W is monoalkylamino with 1 and 6 C, mono [(cycloalkyl) alkyl] amino with 3 and 6 C in cycloalkyl and 1 and 3 C in alkyl; dialkylamino having 2 and 6 C, or halogen; and their pharmacologically acceptable salts with organic or inorganic acids. The process for producing tetracycline of the formula I wherein W is not halogen, is a compound of formula I wherein W is halogen, and the nucleophilic compound W'H, wherein W 'is W except halogen. The process for producing tetracycline of the formula I, for the production of a compound wherein W is halogen, is a compound of the formula X with a haloacyl halide (R.sup.3, R.sup. .4.n., Y) CC (= O) Q, where Y and Q are always halogen, or to form a compound of formula X for the preparation of all compounds of formula I, with the appropriate chloride. acids of formula (R.sup.3, R.sup.4, W) CC (= O) X wherein X is halogen. The tetracyclines of general formula I for use in the prevention or control of bacterial infections in warm blood, including bacterial infections with TetM and TetK resistance determinants. Pharmaceutical and veterinary use of these compounds. \ T |