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filingDate 1994-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_453816bc8b5f7403e9920e9627f5af21
publicationDate 2001-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-288984-B6
titleOfInvention A pharmaceutical composition for inhibiting Alzheimer's disease, for increasing TGF-beta expression in the brain, for inhibiting inflammatory response associated with Alzheimer's disease, and for inhibiting beta-amyloid peptide-mediated neurotoxicity
abstract The invention further relates to the use of the compound benzothiophene of the general formula I in which R 1 is 1. and R.sup.3.n. is a hydrogen atom, a methyl group or a group of formula (a) or (b), Ar is a phenyl group substituted with one or two alkyl groups having 1 and 6 carbon atoms, an alkoxy group having 1 and 4 carbon atoms with a hydroxy group, a nitro group, a chlorine atom, a fluorine atom, or a tri (chloro or fluoro) methyl group, R 5, R 2, R 2. is selected from the group consisting of pyrrolidino and piperidino, for the manufacture of a pharmaceutical composition for the inhibition of Alzheimer's disease, for the TGF-beta family. expression in the brain, inhibition of responsiveness associated with Alzheimer's disease, and inhibition of beta-amyloid peptide mediated neurotoxicity.
priorityDate 1993-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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