abstract |
The invention further relates to the use of the compound benzothiophene of the general formula I in which R 1 is 1. and R.sup.3.n. is a hydrogen atom, a methyl group or a group of formula (a) or (b), Ar is a phenyl group substituted with one or two alkyl groups having 1 and 6 carbon atoms, an alkoxy group having 1 and 4 carbon atoms with a hydroxy group, a nitro group, a chlorine atom, a fluorine atom, or a tri (chloro or fluoro) methyl group, R 5, R 2, R 2. is selected from the group consisting of pyrrolidino and piperidino, for the manufacture of a pharmaceutical composition for the inhibition of Alzheimer's disease, for the TGF-beta family. expression in the brain, inhibition of responsiveness associated with Alzheimer's disease, and inhibition of beta-amyloid peptide mediated neurotoxicity. |