http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-288042-B6
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f5033fcf56d5a13743728cc85a8dc3f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate | 1996-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3386b61e3a6b952d25acc3d003da7e7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71b283d89c8b7276d6142b5baede3c32 |
| publicationDate | 2001-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-288042-B6 |
| titleOfInvention | Process for preparing enantiomerically pure imidazolyl compounds and an imidazolyl compound |
| abstract | The present invention relates to a process for the preparation of enantiomerically pure imidazolyl compounds of formula I wherein n is 0 or 1, m is 1 or 2, R is 1. is hydrogen, methyl or ethyl and C * is a chiral center, as well as pharmaceutically acceptable acid addition salts thereof, wherein a carboxylic acid in an optically active form is added to a solution of the racemic mixture of formula I, followed by In the first crystallization, the crystallized addition salt of said mixture of enantiomers of the compound of formula I is enriched with one enantiomer from the mother liquor enriched in the second enantiomer, wherein the carboxylic acid is pyroglutamic acid. The present invention also relates to an imidazolyl compound of the formula I wherein n and m are 1, R < 1 > is methyl and C * has the R configuration, in the form of hydrochloride monohydrate, having in particular improved resistance to the presence of lubricants. |
| priorityDate | 1995-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.