| abstract |
Substituted pyrazoles of the general formula I, wherein R 1 is 1. is hydrogen or phenyl; R.sub.3.n. C 1 -C 6 alkyl; X.sub.1.n. represents a covalent bond or a sulfur atom; Y is phenyl which is substituted with one to three substituents independently selected from fluoro, chloro, bromo and methyl and / or one with trifluoromethyl; R.sub.4.n. represents a hydrogen atom and R.sub.5 is hydrogen; represents a hydrogen atom or a group of formula -CH.sub.2. or R.sub.4.n. and R.sub.5.n. both represent a group of formula -OR.sub.6.n. and R.sub.6.n. is hydrogen or C 1 -C 6 alkyl; and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical composition for the treatment of: a) diseases caused or facilitated by corticotropin releasing factor; or b) stress and anxiety disorders such as stress-induced depression and headache, bowel irritation syndrome, inflammatory diseases, immune suppression; virus infections |