| abstract |
In the present invention there is disclosed imidazopyridine derivative of the general formula I, in which R represents the group of the general formula a, Re1 represents a fluorine atom, Re2 represents {-SOi2NH-CORe5}, Re3 represents A, Re4 represents {-CinHi2nCO-Nre6Re7}, {-CinHi2nCOOA}, {-CinHi2nCOOH}, {-CinHi2nAr}, {-CinHi2nCOAr} or {-CinHi2nCOA}, Re5 represents A, {-CitHi2t-cycloalkyl} containing 3 to 8 carbon atoms in the cycloalkyl moiety, {-CitHi2t-Ar} or {-O-CitHi2t-Ar}, Re6 and Re7 each represents hydrogen, A, {ArCinHi2n} or Re6 and Re7 together represent also alkylene containing 2 to 5 carbon atoms, A represents alkyl containing 1 to 6 carbon atoms, Ar represents phenyl, t is always zero, 1, 2, 3 or 4, n is 1, 2, 3, 4, 5 or 6. The above-described derivative and physiologically acceptable salts exhibit antagonistic properties against angiotensin II and they are therefore suitable for preparing pharmaceutical preparations intended for treating high pressure of blood, aldosteronism, heart insufficiency and increased intra-ocular pressure and for treating disorders of central nervous system. |