abstract |
The present invention relates to the use of a compound of formula (I) for the preparation of a pharmaceutical composition for minimizing and managing ischemic and reperfusion injury. In the general formula (I), optionally, the chiral center for A is DL, preferably D, L for Pro and L for Arg, Z is C 1 -C 4 alkyl or hydrogen, X NH 2. , NHZ, tert-butyloxycarbonyl-NH or trifluoroacetyl-NH, R is hydrogen, hydroxyl, halogen, alkoxy of 1 to 4 carbon atoms, trifluoromethyl, C1-4 alkyl, NO or NH.sub.2 is selected from the group CH.sub.2 or CO.sub.2 |