| abstract |
Disclosed is a process for the preparation of compounds of formula I wherein Im represents an imidazolyl group of formula (a) and R.sup.1. is hydrogen, C.sub.1-6n.-alkyl, -CH.sub.2 -.sub.2-n-alkynyl or C.sub.3-7.n.- n-alkyl, n is 2 or 3, Q is halogen, hydroxy, phenyl-C 1-8 -alkoxy, C 1-6 alkyl N-alkyl or cyano, Q 'is hydrogen or fluorine and their physiologically acceptable salts and solvates thereof. The compounds of formula (I) are potent and selective 5-hydroxytryptamine (5-HT) antagonists at the 5-H 2 S-3 receptors. |