| abstract |
The method of isotopically labeling peptides to obtain peptides containing isotopes of hydrogen is that the peptide with the free N-terminal amino group is heated in neutral or mildly alkaline medium at a pH of 7 to 11 at a temperature of 30 to 130. isotopes of hydrogen, wherein the isotopes of hydrogen are introduced to the carbon of the first, first and second, optionally first, second and third amine acids in the peptide chain. An advantage is a peptide which contains glycine in the 1-position or in the 1-position and 2-position |