| abstract |
Compounds of the formula <CHEM> wherein X is -O- or -CH2-; Y is -O-, -CH2-CH2-, -CH=CH-, -C IDENTICAL C- or -OCH2C6H4-; Z is -CH2-CH2-, -CH=CH- or -C IDENTICAL C-; R<1> is hydrogen, lower alkyl, lower alkenyl, cycloalkyl or aralkyl; A is -B or -O-B; B is a mono-, di- or tricyclic aromatic or heteroaromatic moiety substituted by the group -COR<2>, -(O)t-(W)s-COR<2>or -(CH=CH)pCOR<2> and which may also contain up to 4 additional substituents selected, independently, from the group consisting of halogen, cyano, lower alkyl, lower alkoxy, sulfonamido, alkanoyl, aroyl, -(Q)k-(W)s'-E or -(Q)k-(W)s''- C6H4-(W)s'''-E, provided that no more than one of said substituents is -(Q)k-(W)s'-E or -(Q)k-(W)s''-C6H4-(W)s'''-E; E is -COR<2> or R<2>; W is -CR<3>R<4>-; Q is -O- or carbonyl; R<2> is hydroxy, lower alkoxy or -NR<3>R<4>; R<3> and R<4> , each occurence, independently, are hydrogen or lower alkyl; f, h, k, m and t, independently, are 0 or 1; n, s and s', independently, are an integer from 1 to 12; p is an integer from 1 to 2; s'' and s''', independently, are a integer from 0 to 12; and C6H4 is a 1,2-, 1,3- or 1,4-phenylene moiety, their geometric and optical isomers and, when R<2> hydroxy, pharmaceutically acceptable salts thereof with bases are potent leukotriene B4 antagonists and are therefore useful in the treatment of inflammatory diseases, such as psoriasis, inflammatory bowel diseases, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, ischemia/reperfusion injury, and trauma induced inflammation, such as spinal cord injury. |