| abstract |
A compound of formula (I), or a salt thereof, wherein n is 0, 1 or 2; and R is a group of formulae (II) to (XXI), wherein: the S(O)nCH2CH2CH=CF2 group is at least one of R1 (when attached to a carbon atom), R2, R3, R4, R5 or R6; R1 (when attached to a carbon atom), R2, R3, R4, R5 and R6 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, alkoxy, alkenyloxy, alkynyloxy, hydroxyalkyl, alkoxyalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxy, optionally substituted heteroarylalkoxy, optionally substituted heteroaryloxyalkyl, haloalkyl, haloalkenyl, haloalkynyl, haloalkoxy, haloalkenyloxy, haloalkynyloxy, halogen, hydroxy, cyano, nitro, -NR7R8, -NR7COR8, -NR7CSR8, -NR7SO2R8, -N(SO2R7)(SO2R8), -COR7, -CONR7R8, -alkylCONR7R8, CR7NR8, -COOR7, -OCOR7, -SR7, -SOR7, SO2R7, -alkylSR7, -alkylSOR7, -alkylSO2R7, -OSO2R7, -SO2NR7R8, -CSNR7R8, SiR7R8R9, -OCH2CO2R7, -OCH2CH2CO2R7, -CONR7SO2R8, -alkylCONR7SO2R8, -NHCONR7R8, -NHCSNR7R8, or an adjacent pair of R1, R2, R3, R4, R5 and R6 when taken together form a fused 5- or 6-membered carbocyclic or heterocyclic ring; R1 (when attached to a nitrogen atom) is hydrogen, optionally substituted alkyl, cycloalkyl, alkylcycloalkyl, hydroxyalkyl, alkoxyalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryl, optionally substituted heteroarylakyl, optionally substituted heteroaryloxyalkyl, haloalkyl, hydroxy, cyano, nitro, -NR7R8, -NR7COR8, NR7CSR8, -NR7COOR8, -NR7SO2R8, -N(SO2R7)(SO2R8), -COR7, -CONR7R8, -alkylCONR7R8, -CR7NR8, -COOR7, -OCOR7, -SOR7, -SO2R7, -alkylSR7, -alkylSOR7, -alkylSO2R7, -OSO2R7, -SO2NR7NR8, -SR7, -SOR7, -SO2R7, -CSNR7R8, -SiR7R8R7, -OCH2CO2R7, -OCH2CH2CO2R7, -CONR7SO2R8, -alkylCONR7SO2R8, -NHCOR7R8, or -NHCSR7R8; and R7, R8 and R9 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, alkynyl, optionally substituted aryl or optionally substituted arylalkyl, haloalkyl, haloalkenyl, haloalkynyl, halogen, or hydroxy. |