| abstract |
This invention provides pharmaceutical benzothiophene compounds of the formula <CHEM> wherein R<1> is hydrogen, hydroxy, C1-C4 alkoxy, <CHEM> wherein Ar is optionally substituted phenyl, or -SO2(C4-C6 straight chain alkyl); R<2> is R<1>, Cl or F; and R<3> and R<4> are, independently, C1-C4 alkyl or combine to form a C4-C6 polymethylene or, together with the nitrogen to which they are attached form morpholine, X is -CH2, -CHOH2-, -O-, or <CHEM> or a pharmaceutically acceptable salt or solvate thereof. s |