| abstract |
Compounds of formula (I) wherein Z represents a methylene group, a methine group, a group of formula >NH or a group of formula >N-, and W represents a methylene group, a methine group, a sulfur atom or a group of formula mu S}(O)v, where <u>v</u> is 1 or 2; <u>...</u> is a single or double bond; at least one of Y<1>, Y<2>, Y<3> and Y<4> represents a carboxyl group, a sulfonamide group or a group of formula -(A)p-B<1>-T<1>, wherein A is S or O, T<1> is a carboxyl group, a thiocarboxy group, a dithiocarboxy group, a sulfonamide group or a tetrazolyl group, B<1> is a bond, an optionally substituted alkylene group and <u>p</u> is 0 or 1; the rest of Y<1>, Y<2>, Y<3> and Y<4> are the same or different and are H, halogen, nitro, OH, SH, NH2, optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aryl, aralkyloxy, aralkylthio and Y<1> + Y<2> may together be a lactone or keto; one of R<1> and R<2> is H, alkyl, alkanoyl, aryl, arylcarbonyl, aralkyl, carboxyl, sulfonamide or a group of formula -(O)q-B<2>-T<2>, wherein T<2> is COOH, sulfonamide or tetrazolyl, B<2> is an optionally substituted alkylene, and <u>q</u> is 0 or 1; the other of R<1> and R<2> is H, alkyl, aryl or aralkyl, or R<1> and R<2> together represent a group of formula (Ib'), wherein [R<10>, R<11> and R<12> are the same or different and each is H, OH, halogen, haloalkyl, optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl]; R<3> is H or an amino protecting group; and pharmaceutically acceptable salts and esters thereof are allosteric effectors at muscarinic receptors, and are useful in the treatment and prophylaxis of disorders associated with muscarinic receptors. |