| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad3d51747a2eba1e7636894263252df4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4422
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate |
1993-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20f3567dc247f4b6921c117d6d867301
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f56edbfba6da408f225815fe4ce429a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a47ede82673a4fd388b633d2bd44284f |
| publicationDate |
1994-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CZ-216593-A3 |
| titleOfInvention |
Process for preparing amlodipinebenzenesulfonate |
| abstract |
There is disclosed a process for the preparation of 3-ethyl 5-methyl (+/-) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4- dihydro-6-methyl-3,5-pyridine-dicarboxylate monobenzenesulphonate (amlodipine benzenesulphonate) of formula <CHEM> wherein 3-ethyl 5-methyl (+/-) 2-[2-(N-tritylamino)-ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-me thyl-3,5- pyridinedicarboxylate is reacted with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature from 20 DEG C to the reflux temperature and the title compound is isolated and purified. Amlodipine benzene sulphonate is a valuable anti-ischaemic and anti-hypertensive agent. |
| priorityDate |
1992-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |