| abstract |
Cardioprotective active ingredients based on an analog of ICRF-193 of the formula I, in which R1, R2 = H, 2-R3-2-aminoacetoxymethyl, where R3 is selected from the group consisting of H, C1-C6 alkyl or branched alkyl or benzyl. These compounds can be prepared by simple syntheses and are characterized by low toxicity and high efficacy against chronic cumulative cardiotoxicity caused by anthracycline antitumor drug therapy. Also provided is a pharmaceutical composition comprising a compound of formula I as an active ingredient, as well as the use of this compound for the manufacture of a pharmaceutical composition for the prevention of chronic cumulative cardiotoxicity due to anthracycline antitumor drug therapy. |