http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-2018248-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fece74aa8c0cb73d997c194165159cc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd65d2c1adcec7411f91d0362b1a5156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_223dc6cb9c315f8cfed1d9eed6a55ed6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d5a217910318814f44afb1714eb5f90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c4042bcc76321e9791d8be315b1dbfd |
| publicationDate | 2019-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-2018248-A3 |
| titleOfInvention | Method for the preparation of tenapanor |
| abstract | The present invention relates to a novel process for the preparation of tenapanor which is based on the use of a diamine of formula VIII as the starting material. The new process for the preparation of tenapanor leads to a crystalline product in each step and thus increases both the purity and yield of the resulting product. Further, the process allows the expensive chiral-pure input () -3- (6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl) benzenesulfonyl chloride of formula III to enter the process at a later stage, and thus, it further increases the yield of the entire process relative to this feed. |
| priorityDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.