| abstract |
The present invention provides novel arylbenzothiazolylurea derivatives of Formula I, and pharmaceutically acceptable alkali metal, ammonia or amine salts thereof, or acid addition salts thereof, wherein R is selected from -COOH, -COO (C 1 -C 4 alkyl), -CONH, - CONH (C 1 -C 4 alkyl), -CON (C 1 -C 4 alkyl), -NH, -NH (C 1 -C 4 alkyl), -N (C 1 -C 4 alkyl), -NHCO (C 1 -C 4 alkyl), -N ( C 1 -C 2 alkyl) CO (C 1 -C 4 alkyl). These novel aryl benzothiazolyl urea derivatives are inhibitors of betaamyloid alcohol dehydrogenase (ABAD) enzymatic activity. The solution further provides a method for their preparation and their therapeutic use for the treatment of Alzheimer's disease and / or dementia. |