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filingDate 2017-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d044cc3721ff47cdb49ad2c5bc212dc8
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publicationDate 2019-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-2017427-A3
titleOfInvention Composite vascular replacement and method of its production
abstract The present invention relates to a composite vascular surrogate, particularly for a flow rate below 100 ml / min and an internal diameter of less than 6 mm, which includes a non-absorbable knitted fabric layer (2) which is coated with a collagen material on the inside and outside. Preferably, the non-absorbable layer (2) of knitted fabric is placed on a self-supporting inner absorbable layer (1) of collagen mass, the non-absorbable layer (2) being covered with an intermediate layer (4) of collagen mass on which the outer absorbent layer (3) is made of collagenous mass. It further relates to a method for producing such a vascular substitute, wherein the collagen mass is at a concentration of 4 to 12% by weight. the collagen is thermostated at 15 to 30 ° C for 18 to 30 hours, whereupon the non-absorbable knitted layer (2) integrates into one collagen layer to form a collagen coating on the inside and outside of the non-absorbable knitted fabric (2) or collagen. a mass of 4 to 12 wt. the collagen is extruded from the collagen mass through an inner absorbent layer (1) in the form of a tube which is dried at room temperature to a supple state, then strung onto the inner absorbent layer (1) a non-absorbable layer (2) of knitted fabric on which the outer absorbable layer (3) of collagen mass is extruded at a concentration of 3 to 12% wt. collagen and vascular substitutes are dried at 15 to 30 ° C for 15 to 30 hours until supple, whereupon vascular substitutes are cured with 1.5 to 3.2% resin for 3 to 10 min and then dried and spun. 15-30% glycerin in the bath for 15-25 minutes.
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type http://data.epo.org/linked-data/def/patent/Publication

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