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filingDate 2016-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2017-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-2016311-A3
titleOfInvention Coated spherical pellets, their production and adjustment in detection tubes to detect cholinesterase inhibitors
abstract Spherical pellets containing an immobilized cholinesterase-based enzyme having an activity of 1 to 100 nkat.g.sup.-1.n., wherein the enzyme is immobilized in the form of a solid dispersion in a hydrophilic polymer which forms the primary pellet shell at a concentration of 5-15% by weight. a coated pellet which is subsequently coated with a secondary semipermeable water-insoluble polymer coating at a concentration of 1-10% by weight. coated pellets, wherein the average size of the coated pellets is at least 75% in the size range of 0.1 to 3.0 mm, preferably 0.8 to 1.25 mm, as well as a process for producing the pellet cores to be coated followed by a secondary package which is produced by extrusion-spheronization or photographing, the pellet cores being coated in both the fluidized bed (primary and secondary) and the resulting coated pellets used to detect cholinesterase inhibitors in the form of a detection tube containing said coated pellets. spherical pellets.
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