| abstract |
The 2-phenyl-3-hydroxyquinolin-4 (1H) -one derivatives of formula I wherein R 1 is a hydrogen atom or a COR group, wherein the R ligand consists of an oligopeptide chain of 1-5 amino acids, the amino acid of which is may be glycine, alanine, leucine, isoleucine, valine, cysteine, threonine, methionine, aspartic acid, asparagine, tyrosine, lysine, glutamic acid, glutamine, arginine, hystidine, phenylalanine, tryptophan, proline. R5 is hydrogen, alkyl or cycloalkyl, wherein the individual hydrogen atoms of the alkyl / cycloalkyl chain may be replaced by hydroxy groups, while the carbon atoms of the alkyl / cycloalkyl chain may be replaced by hydroxyl groups; the chains may be replaced by oxygen or sulfur atoms. Said derivatives are compounds having activity against tumor cells and further enhanced pharmacological properties such as solubility and bioavailability. They are therefore suitable as pharmaceutical compositions for use in medicine. |