| abstract |
Method for isolating the E1 and E2 optical isomers, forming an enantiomeric mixture, from a mixture of four optical isomers E1, E2, E3, E4, first separating the E3 and E4 enantiomeric mixture from the solution, and subsequently isolating the base E1 and E2 mixture in the mother liquors, wherein E1 is (1R, 2S) -1- (6-bromo-2-methoxyquinolin-3-yl) -4- (dimethylamino) -2- (naphthalen-1-yl) -1-phenylbutan-2-ol E2 ( The 1S, 2R) -enantiomer of the same compound, E3 and R4 are (1R, 2R) and (1R, 2R) respectively. (1S, 2S) enantiomers. |