| abstract |
5-Substituted 7- [4- (2-pyridyl) phenylmethylamino] -3-isopropylpyrazolo [4,3-d] pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases CDK2 and CDK5, and exhibit antileukemic, proapooptotic, antiangiogenic anticancer effects. The invention further relates to processes for their preparation, pharmaceutical compositions comprising these compounds, and their use for treatment, in particular diseases associated with proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid tumors. |