abstract |
The present invention relates to a process for the preparation of glycopyrronium bromide in the form of [R, S] and [S, R] diastereoisomers, wherein the process consists of crystallizing the desired diastereoisomers from a mixture of diastereoisomers [R, S], [S, R], [R, R]. and [S, S] two or more controlled crystallizations from a solution of a solvent selected from 1-propanol, 2-propanol, 1-butanol, tert-butanol. |