| abstract |
The present invention relates to canagliflozin complexes of formula I, (1S) -1,5-Anhydro-1- (3 - ((5- (4-fluorophenyl) -2-thienyl) methyl) -4-methylphenyl) -D-glucitol, with cyclodextrins and their method of preparation. These complexes can be advantageously used to stabilize amorphous canagliflozin in terms of both chemical and polymorphic stability. Above all, beta-cyclodextrin, modified beta-cyclodextrins and gamma-cyclodextrin can be used for the complexation of canagliflozin. |