| abstract |
SUMMARY OF THE INVENTION The present invention relates to cholic hydrazones of the formulas I-V wherein the meanings of the general substituents are set forth in the specification. The conjugates consist of a covalently linked biologically active moiety, a hydrazone with a bioavailability enhancing moiety, and a cholic moiety. These agents have a cytostatic effect and can be used to prepare therapeutics for the treatment of cancer and leukemia. |