| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-46 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-06 |
| filingDate |
2012-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b09c7dd78af9a41c2d56484cd269ebe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67ba19c3ee4da971b4ecfe53d9915ae4 |
| publicationDate |
2013-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CZ-2012226-A3 |
| titleOfInvention |
Process for preparing di- (2-thienyl) glycolic acid scopine ester intermediate in the synthesis of tiotropium bromide |
| abstract |
The invention relates to a process for the preparation of tiotropium bromide of formula II, comprising the steps of: a) preparing a scopine ester of formula I by transesterification of methyl di (2-thienyl) glycollate of formula IV with scopine of formula III in the presence of a substoichiometric amount of a sterically hindered base selected from branched C3 alkali salts and (c) quaternizing the scopine ester of formula (I) with methyl bromide. |
| priorityDate |
2012-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |