http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-2012178-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-32 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B37-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-12 |
| filingDate | 2012-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67ba19c3ee4da971b4ecfe53d9915ae4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8be4394013220f7f2966d2ca8f2dc9b |
| publicationDate | 2013-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-2012178-A3 |
| titleOfInvention | Production method of 3 - (((2R, 3S) -2 - ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholino) methyl) -1H-1 , 2,4-triazol-5 (4H) -one (Aprepitant) in polymorphic form II |
| abstract | The present invention relates to a process for the preparation of aprepitant of formula 1, in the desired crystal form II or I, wherein the intermediate of formula 12 is extracted into a water immiscible high boiling solvent selected from an alcohol, an ester or a ketone and after washing with water and / or brine, the solution is heated to the boiling point. solvent when cyclization to aprepitant occurs, and upon cooling, the resulting aprepitant is isolated. |
| priorityDate | 2012-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.