http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-201126-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91079231f0414d59e353e14ddf9cd136 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-44 |
| filingDate | 2011-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aecf5494092362f399b6eb59814ed272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0164a9b1a76c58cac41a60cef52b24fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72665dc7bcac047a9e461fc72a14ef46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6d110ef383b0df4123074aa5dd73819 |
| publicationDate | 2012-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-201126-A3 |
| titleOfInvention | A method for producing substituted phosphonic diamides |
| abstract | A method for producing substituted phosphonic acid diamides, wherein the corresponding bis (trialkylsilyl) phosphonic acid esters are reacted with an alkyl- or aryl ester-encoded amino acid of C.sub.3.n.-C.sub.16.n. or the hydrochloride of such compounds. , in the presence of a polar organic solvent, an organic base and a reactant for the activation and exchange of oxygen at the phosphonic function, heating the reaction mixture for 1 to 6 hours at a temperature of 40 to 100 degC depending on the bulk of the introduced amino acid to produce the desired products high yield and purity required for drug substance. These products can be used as prodrugs of biologically active phosphonic acids. |
| priorityDate | 2011-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.