| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8faf71a78bf0e9b2d4b7357812d84ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97f111dd11492774a1d7a36ad4608433 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate |
2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07f00549be50f48f21ad76baf221cbf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64e10df7910be332550ebb5d46a1ac42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07cb0012849154e6bca77de2ec0d23b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ade0904d8a245bc4c369b7cebd2c9c23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6498cc8b2ed23de0f9c854e61f266746
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01ba4ee473baf2ec9682257e67633101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bcdef5c70d699b0e076f08be091713a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6bbc481c7a9382f883c7d8dc51a1a7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b2c5a0dfac99706a53a1230aa0c674d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_983ff8a3fa8c7636eaa4b9e3729be97f |
| publicationDate |
2011-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CZ-2009725-A3 |
| titleOfInvention |
Cholestane derivatives for use as anticancer and anti-angiogenic drugs and pharmaceutical preparations containing these |
| abstract |
The present invention relates to cholestane derivatives and pharmaceutical compositions thereof for use as antitumor and antiangiogenic drugs, including a method for reducing the growth or complete and selective proliferation capacity of tumor cells. The invention also encompasses methods for arresting the cell cycle using cholestane derivatives resulting from apoptotic changes in the tumor cell. The invention also provides the use of these agents to inhibit angiogenesis through inhibition of migration and tubule formation of human endothelial cells. The invention encompasses their use in the control of the adverse effects of hyperpoliferation and angiogenesis of mammalian cells in vitro and in vivo, in particular the treatment of hyperproliferative diseases in a mammal by means of a composition comprising cholestane derivatives. The present invention also discloses novel therapeutic methods for modifying proliferation and invasion of breast and prostate tumor cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022083809-A1 |
| priorityDate |
2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |