http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-2009399-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3420e9bf75ae09a97f74572c9ecb6221 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 |
| filingDate | 2009-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b82a48703310e2ea143820f3fd8a79c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_570f8358d6ab841e40ea0de77fafda94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_854cd361d28c83f4a3e83011460c9f8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d64128363e93d3847fab98c10a9052a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9889e4913b23295a6a7e7c56464fcdf0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c65cee72fb7b0a19869d2c9a6bee13a |
| publicationDate | 2011-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-2009399-A3 |
| titleOfInvention | A method for preparing a hyaluronan ester |
| abstract | The present invention relates to a process for the preparation of a hyaluronan ester wherein the hyaluronan bearing the COOH or COO group is dissolved in water, the solution is cooled to room temperature and a water-miscible organic solvent is added. Subsequently, the esterification agent RX or XZX is added, wherein R and Z are aliphatic, cycloaliphatic, olefinic, arylaliphatic or heterocyclic radicals having carbon numbers of 1 to 18, optionally containing hydroxy and / or disulfide bonds, and X is Cl, Br or l The resulting reaction mixture is stirred for 1 hour to 6 days while maintaining the pH of the reaction mixture at 6 to 10, whereby the pH of the reaction mixture can be maintained at 7 by the gradual addition of Na.sup. (n = 1, 2, 3), wherein Y.sup.n-.n is selected from the group consisting of OH.sup.in., HCO.sub.3.nup.-. n., CO.sub.3.n..sup.2-.n., PO.sub.4.n..sup.3-.n., HPO.sub.4.n..sup.2- .n., H.sub.2.n.PO.sub.4.n..sup .-. n., F.sup .-. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11425907-B2 |
| priorityDate | 2009-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.