http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-2008107-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 2008-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cecda45bf389f6bb1ddad2ce7533260 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67ba19c3ee4da971b4ecfe53d9915ae4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57026ba0204ad0b3c7a610822b985b44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8be4394013220f7f2966d2ca8f2dc9b |
| publicationDate | 2010-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CZ-2008107-A3 |
| titleOfInvention | Process for producing (3R, 4S) -1- (4-fluorophenyl) -3 - [(3S) -3- (4-fluorophenyl) -3-hydroxypropyl)] - 4- (4-hydroxyphenyl) -2-azetidinone |
| abstract | A process for producing (S) -alcohol-oxazolidide of formula (II) wherein PG is hydrogen or a hydroxyl protecting group such as trimethylsilyl, tert -butyldimethylsilyl, benzyloxycarbonyl, tert -butoxycarbonyl, benzyl, benzhydryl or trityl, an oxazolidide of formula III wherein PG is the same as above and R is alkyl of 1-4 carbon atoms, linear or branched, such as methyl, ethyl, isopropyl, or butyl, or R + R together is a divalent alkyl optionally substituted with 1 or 2 alkyl groups, such as 1,2-ethylene, 1,2-propylene, 1,2-butylene, 1,3-propylene or 2,2-dimethyl-1,3-propylene, to remove acidic agents in the water mixture and water miscible solvent in the range of 0 to 100 degC (step A), and the obtained ketone oxazolidide of formula IV, wherein PG is as defined above, is reduced by asymmetric agents in an inert organic solvent at a temperature range of -30 to + 40 degC (Grade B). |
| priorityDate | 2008-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 165.