| abstract |
The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-(4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl)-acrylicacid, as selective estrogen receptor modulators. Also provided are methods for the treatment and/or prevention of estrogen stimulated diseases in mammalsincluding breast, uterine, ovarian, prostrate and colon cancer, osteoporosis,cardiovascular disease, and benign proliferative disorders, as well as pharmaceuticalcompositions of the compounds of the present invention. |