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publicationDate 2006-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CZ-20041002-A3
titleOfInvention A method for preparing an oral solid dosage form and an oral solid dosage form prepared by this method
abstract A process for the preparation of an oral solid dosage form capable of immediate release of an active substance which is a water-soluble antiestrogen, in particular tamoxifen citrate, is admixed with a water-insoluble and / or alcohol-insoluble filler and optionally with at least one other pharmaceutically acceptable excipient. the filler or mixture thereof with at least one other pharmaceutically acceptable excipient has a size of less than 355 microns and no more than 10% of these particles have a size of less than 40 microns, then the triturate obtained is mixed with a water-soluble and / or alcohol-soluble filler and water-soluble or and the mixture obtained is granulated in the presence of water and / or alcohol which are used in an amount not greater than 8% by weight and the granulate obtained is dried. The oral solid dosage forms thus prepared are described.
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