| abstract |
The invention relates to indolinones, substituted in position 6, of general formula (I), in which R1 to R5 and X are defined as per claim (1). The invention also relates to their isomers and salts, in particular to their physiologically compatible salts, which have valuable pharmacological properties, specifically an inhibiting action on various receptor tyrosine kinases and cyclin/CDK complexes, in addition to on the proliferation of endothelium cells and various tumour cells. The invention further relates to medicaments containing said compounds, to the use of said medicaments and to a method for their production. |